Inflammatory biomarkers, disease activity and spinal disease measures in patients with ankylosing spondylitis after treatment with infliximab.

  • Visvanathan S
  • Wagner C
  • Marini J
 et al. 
  • 45

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Abstract

OBJECTIVE: To evaluate the relationship between biomarker levels and disease activity and the spinal inflammation detected by magnetic resonance imaging (MRI) in patients with ankylosing spondylitis (AS). METHODS: Patients with AS were randomly assigned in a 3:8 ratio to receive infusions of placebo or 5 mg/kg infliximab at weeks 0, 2, 6, 12 and 18. Sera were collected for biomarker analysis at weeks 0, 2 and 24 and were analysed for levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and C-reactive protein (CRP). Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores and pre- and post-gadolinium T1 and short tau inversion recovery MRIs were collected at baseline and week 24. RESULTS: Significantly greater reductions in IL-6, VEGF and CRP were observed at weeks 2 and 24 in the infliximab group compared with the placebo group (all p7.38 pg/ml and CRP levels >1.5 mg/dl were associated with increased rates of clinical response after 24 weeks. Multiple regression analyses showed that reductions from baseline to week 2 in IL-6, but not CRP or VEGF, were significantly associated with reductions in MRI activity and BASDAI scores from baseline to week 24 in the infliximab group (p

Author-supplied keywords

  • Ankylosing
  • Ankylosing: blood
  • Ankylosing: drug therapy
  • Antibodies
  • Antirheumatic Agents
  • Antirheumatic Agents: therapeutic use
  • Biological Markers
  • Biological Markers: blood
  • C-Reactive Protein
  • C-Reactive Protein: metabolism
  • Female
  • Humans
  • Interleukin-6
  • Interleukin-6: blood
  • Magnetic Resonance Imaging
  • Male
  • Monoclonal
  • Monoclonal: therapeutic use
  • Predictive Value of Tests
  • Severity of Illness Index
  • Spondylitis
  • Treatment Outcome
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor A: blood

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Authors

  • S Visvanathan

  • C Wagner

  • J C Marini

  • D Baker

  • T Gathany

  • J Han

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