Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases

  • Martinon F
  • Tschopp J
  • 333

    Readers

    Mendeley users who have this article in their library.
  • 673

    Citations

    Citations of this article.

Abstract

Caspases not only play an essential role during apoptotic cell death, but a subfamily of them - the inflammatory caspases - are associated with immune responses to microbial pathogens. Activation of inflammatory caspases, such as caspase-1 and caspase-5, occurs upon assembly of an intracellular complex, designated the inflammasome. This results in the cleavage and activation of the proinflammatory cytokines IL-1β and IL-18. Mutations in one of the scaffold proteins of the inflammasome, NALP3/Cryopyrin, are associated with autoinflammatory disorders underscoring the importance of regulating inflammatory caspase activation.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free