Influence of adenosine A(1)-receptor blockade and vagotomy on the gasping and heart rate response to hypoxia in rats during early postnatal maturation.

  • Fewell J
  • Zhang C
  • Gillis A
  • 9


    Mendeley users who have this article in their library.
  • 15


    Citations of this article.


Failure to autoresuscitate from apnea has been suggested to play a role in sudden infant death. Little is known, however, about factors that influence the gasping and heart rate response to severe hypoxia that are fundamental to successful autoresuscitation in the newborn. The present experiments were carried out on 184 rat pups to investigate the influence of the parasympathetic nervous system, as well as adenosine, in mediating the profound bradycardia that occurs with the onset of hypoxic-induced primary apnea and in modulating hypoxic gasping. On days 1 to 2, days 5 to 6, and days 10 to 11 postpartum and following bilateral cervical vagotomy (VAG) or administration of a selective adenosine A(1) receptor antagonist (8-cyclopentyl-1,3-dipropylxanthine; DPCPX), each pup was exposed to a single period of severe hypoxia produced by breathing an anoxic gas mixture (97% N(2)-3% CO(2)). Exposure to severe hypoxia resulted in an age-dependent decrease in heart rate (P < 0.001), accentuated with increasing postnatal age, that was attenuated in all age groups by DPCPX but not by VAG. Furthermore, DPCPX but not VAG decreased the time to last gasp but increased the total number of gasps in the 1- to 2-day-old and 5- to 6-day-old pups but not in the 10- to 11-day-old pups during exposure to severe hypoxia. Thus our data provide evidence that adenosine acting via adenosine A(1) receptors plays a role in modulating hypoxic gasping and in mediating the profound bradycardia that occurs coincident with hypoxic-induced primary apnea in rats during early postnatal life.

Author-supplied keywords

  • Adenosine
  • Adenosine A1 Receptor Agonists
  • Adenosine A1 Receptor Antagonists
  • Adenosine: analogs & derivatives
  • Adenosine: pharmacology
  • Animals
  • Animals, Newborn
  • Animals, Newborn: physiology
  • Anoxia
  • Anoxia: physiopathology
  • Dose-Response Relationship, Drug
  • Forelimb
  • Heart Rate
  • Heart Rate: drug effects
  • Heart Rate: physiology
  • Parasympathetic Nervous System
  • Parasympathetic Nervous System: drug effects
  • Parasympathetic Nervous System: physiopathology
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Adenosine A1
  • Receptor, Adenosine A1: drug effects
  • Reflex
  • Reflex: drug effects
  • Reflex: physiology
  • Remission, Spontaneous
  • Vagotomy
  • Xanthines
  • Xanthines: pharmacology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • James E Fewell

  • Chunfen Zhang

  • Anne M Gillis

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free