Influence of epicardial and visceral fat on left ventricular diastolic and systolic functions in patients after myocardial infarction

  • Fontes-Carvalho R
  • Fontes-Oliveira M
  • Sampaio F
 et al. 
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Obesity has been associated with subclinical left ventricular (LV) diastolic dysfunction and increased risk of heart failure. Few data are available on the relative contribution of adiposity distribution and changes in myocardial structure and function. We evaluated the influence of visceral versus subcutaneous abdominal adipose tissue and epicardial fat on LV diastolic function after acute myocardial infarction. One month after acute myocardial infarction, 225 consecutive patients were prospectively enrolled and underwent anthropometric evaluation, bioimpedance analysis, detailed echocardiography, and multidetector 64-slice computed tomography scan for quantification of epicardial fat volume (EFV) and of total, subcutaneous and visceral abdominal fat areas. We found a significant association between LV diastolic dysfunction parameters and body mass index, fat-mass percentage, and waist-to-height ratio. E' velocity and E/E' ratio were correlated with total and visceral abdominal fat (r = -0.27, p

Author-supplied keywords

  • *Body Fat Distribution
  • Adult
  • Aged
  • Body Mass Index
  • Cohort Studies
  • Diastole/physiology
  • Female
  • Humans
  • Intra-Abdominal Fat/*radiography
  • Left/etiology/*physiopath
  • Male
  • Middle Aged
  • Multidetector Computed Tomography
  • Myocardial Infarction/*complications
  • Obesity/physiopathology/*radiography
  • Pericardium/*radiography
  • Prospective Studies
  • Stroke Volume/physiology
  • Subcutaneous Fat/*radiography
  • Systole/physiology
  • Ventricular Dysfunction

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  • R Fontes-Carvalho

  • M Fontes-Oliveira

  • F Sampaio

  • J Mancio

  • N Bettencourt

  • M Teixeira

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