Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study. SO - Phytother Res 2015 Aug;29(8):1123-30

  • Rao A
  • Steels E
  • Beccaria G
 et al. 
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

AIM: The aim of the study was to evaluate the effect of Trigonella?foenum-graecum (fenugreek) seed extract on sex hormones and sexual function in healthy menstruating women who reported low sexual drive. This short term, single site, double blind, randomised, placebo-controlled study was conducted on 80 women, aged 20 to 49?years. Participants were randomised to either an oral dose of a standardised T.?foenum-graecum seed extract (libifem) at a dose of 600?mg/day or placebo over two menstrual cycles. Dehydroepiandrosterone sulfate, progesterone, androstenedione, total and free testosterone, estradiol (E2), luteinizing hormone, follicle stimulating hormone, sex hormone binding globulin and cholesterol were measured at baseline and 8?weeks. The individual aspects of sexual function were measured using the Derogatis interview for sexual functioning and female sexual function index self-administered questionnaires. Stress, fatigue and quality of the relationship with partner were also measured using the PSS (Perceived Stress Scale), MFI-20 (Multidimensional Fatigue Inventory) and DAS (Dyadic Adjustment Scale) quality of life measures, respectively. There was a significant increase in free testosterone and E2 in the active group as well as sexual desire and arousal compared with the placebo group. The results indicate that this extract of T.?foenum-graecum may be a useful treatment for increasing sexual arousal and desire in women. [Copyright 2015 John Wiley & Sons, Ltd.].

Author-supplied keywords

  • Administration, Oral
  • Adult
  • Double-Blind Method
  • Estradiol [blood]
  • Humans
  • Libido [drug effects]
  • Middle Aged
  • Plant Extracts [pharmacology]
  • Quality of Life
  • Seeds [chemistry]
  • Testosterone [blood]
  • Trigonella [chemistry]
  • Young Adult

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • A Rao

  • E Steels

  • G Beccaria

  • W J Inder

  • L Vitetta

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free