Innate sensing of bacterial cyclic dinucleotides: More than just STING

  • Bowie A
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Abstract

Bacterial cyclic dinucleotides are recognized by the innate immune system, and this leads to the induction of type I interferons. The mammalian helicase DDX41 directly binds cyclic dinucleotides and mediates the signaling pathway to the induction of type I interferons.

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Authors

  • Andrew G. Bowie

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