Inside the human cancer tyrosine phosphatome

  • Julien S
  • Dubé N
  • Hardy S
 et al. 
  • 245


    Mendeley users who have this article in their library.
  • 238


    Citations of this article.


Members of the protein tyrosine phosphatase (Ptp) family dephosphorylate target proteins and counter the activities of protein tyrosine kinases that are involved in cellular phosphorylation and signalling. As such, certain PTPs might be tumour suppressors. Indeed, PTPs play an important part in the inhibition or control of growth, but accumulating evidence indicates that some PTPs may exert oncogenic functions. Recent large-scale genetic analyses of various human tumours have highlighted the relevance of PTPs either as putative tumour suppressors or as candidate oncoproteins. Progress in understanding the regulation and function of PTPs has provided insights into which PTPs might be potential therapeutic targets in human cancer.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Sofi G. Julien

  • Nadia Dubé

  • Serge Hardy

  • Michel L. Tremblay

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free