Insulin modulates food-related activity in the central nervous system

  • Guthoff M
  • Grichisch Y
  • Canova C
 et al. 
  • 66


    Mendeley users who have this article in their library.
  • 84


    Citations of this article.


CONTEXT: Previous data suggest a key role of central nervous insulin action in regulating energy homeostasis. OBJECTIVE: We therefore investigated whether insulin modulates brain responses to food and nonfood pictures in a functional magnetic resonance imaging study. DESIGN AND PATIENTS: Nine healthy, normal-weight subjects underwent two functional magnetic resonance imaging measurements to compare the effects of insulin and placebo administration during a visual recognition task with food and nonfood pictures. Insulin was administered intranasally to raise insulin concentrations in the cerebrospinal fluid without altering systemic effects in the periphery. Metabolic parameters were continuously determined during the experiments. MAIN OUTCOME MEASURE: We measured the changes in brain activity after intranasal insulin administration. RESULTS: Food pictures were detected faster when compared to nonfood pictures in all conditions without any effect of placebo or insulin. After insulin application, functional magnetic resonance imaging measurements showed a significantly reduced activity in the presence of food pictures compared to placebo in the right and left fusiform gyrus, the right hippocampus, the right temporal superior cortex, and the right frontal middle cortex. The brain activation induced by nonfood pictures remained unaffected by insulin. CONCLUSION: We demonstrate that intranasal insulin led to a reduction of activity in brain areas related to object processing and memory and may have an effect on brain activation with regard to the processing of food pictures. This effect might be part of a mechanism that terminates food intake in the postprandial state.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Martina Guthoff

  • Yuko Grichisch

  • Carlos Canova

  • Otto Tschritter

  • Ralf Veit

  • Manfred Hallschmid

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free