Insulin resistance is common in patients with predominantly genotype 3 chronic hepatitis C.

  • Duseja A
  • Dhiman R
  • Chawla Y
 et al. 
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Abstract

Hepatitis C virus (HCV) infection has been associated with insulin
resistance or diabetes mellitus, but data are controversial on the
role of different HCV genotypes in causing insulin resistance. We
have designed a study aimed at determining insulin resistance in
patients with chronic hepatitis C with predominant genotype 3. Insulin
resistance was measured using a homeostasis model of assessment for
insulin resistance in 85 non-diabetic, non-cirrhotic patients with
chronic hepatitis C (genotype 3 = 54). The results were compared
with 38 biopsy-proven patients with non-alcoholic fatty liver disease
and 25 age- and body mass index-matched healthy volunteers. Patients
with chronic hepatitis C had a higher fasting insulin and homeostasis
model of assessment for insulin resistance values than healthy volunteers
(P = 0.0001). A large number of patients with chronic hepatitis C
showed evidence of insulin resistance than healthy controls [53 (62.3%)
vs. 4 (16%), respectively] (P < 0.0001). Of the various risk factors
studied for insulin resistance in patients with chronic hepatitis
C, higher waist (P = 0.010) and higher serum triglycerides (P = 0.002)
were found to correlate with HOMA-insulin resistance. There was no
difference in insulin resistance amongst patients with genotype 1
or 3, respectively. Based on these results, we conclude that insulin
resistance is common among non-diabetic, non-cirrhotic patients with
chronic hepatitis C. A majority of these patients had genotype 3,
but there was no difference in insulin resistance between genotype
1 and genotype 3 patients.

Author-supplied keywords

  • Adult; Case-Control Studies; Fatty Liver
  • Chronic
  • blood
  • blood/genetics/physiopathology; Female; Genetic P
  • blood/genetics/physiopathology; Humans; Insulin R
  • physiology; Male; Middle Aged; Risk Factors; Trig

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Authors

  • Ajay Duseja

  • R K Dhiman

  • Yogesh Chawla

  • Kiran K Thumburu

  • Amit Kumar

  • Ashim Das

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