Insulin Resistance, Dyslipidemia and Cardiovascular Changes in a Group of Obese Children

  • Pires A
  • Martins P
  • Pereira A
 et al. 
  • 70


    Mendeley users who have this article in their library.
  • 9


    Citations of this article.


INTRODUCTION Obesity-related comorbidities are present in young obese children, providing a platform for early adult cardiovascular disorders. OBJECTIVES To compare and correlate markers of adiposity to metabolic disturbances, vascular and cardiac morphology in a European pediatric obese cohort. METHODS We carried out an observational and transversal analysis in a cohort consisting of 121 obese children of both sexes, between the ages of 6 and 17 years. The control group consisted of 40 children with normal body mass index within the same age range. Markers of adiposity, plasma lipids and lipoproteins, homeostasis model assessment-insulin resistance, common carotid artery intima-media thickness and left ventricular diameters were analyzed. RESULTS There were statistically significant differences between the control and obese groups for the variables analyzed, all higher in the obese group, except for age, high-density lipoprotein cholesterol and adiponectin, higher in the control group. In the obese group, body mass index was directly correlated to left ventricular mass (r=0.542; p=0.001), the homeostasis model assessment-insulin resistance (r=0.378; p=

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • António Pires

  • Paula Martins

  • Ana Margarida Pereira

  • Patricia Vaz Silva

  • Joana Marinho

  • Margarida Marques

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free