Insulin resistance influences central opioid activity in polycystic ovary syndrome

  • Berent-Spillson A
  • Love T
  • Pop-Busui R
 et al. 
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This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin-opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that [1] patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5); [2] receptor availability was correlated with severity of insulin resistance; and [3] receptor availability normalized after insulin-regulating treatment. © 2011 by American Society for Reproductive Medicine.

Author-supplied keywords

  • PCOS
  • Positron emission tomography
  • glucose regulation
  • insulin resistance
  • neuroimaging
  • β-endorphins
  • μ-opioid receptors

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  • Shahrokh PaktinatShahid Beheshti University of Medical Sciences School of Medicine

  • Alison Berent-Spillson

  • Rodica Pop-Busui

  • Maryfran Sowers

  • Carol C. Persad

  • Kathryn P. Pennington

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