This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin-opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that  patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5);  receptor availability was correlated with severity of insulin resistance; and  receptor availability normalized after insulin-regulating treatment. © 2011 by American Society for Reproductive Medicine.
Mendeley saves you time finding and organizing research
Choose a citation style from the tabs below