Insulin-sensitizing effects on muscle and adipose tissue after dietary fiber intake in men and women with metabolic syndrome

  • M.D. R
  • J.W. W
  • E. L
 et al. 
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Abstract

Context: Dietary fibers have been associated with a reduced incidence of type 2 diabetes mellitus in epidemiological studies; however, the precise mechanisms are unknown. Objective: The objective of the study was to evaluate the efficacy and site of action of an insoluble dietary fiber derived from maize (HAM-RS2) in improving insulin resistance in subjects at increased risk of type 2 diabetes mellitus. Design: This study was a randomized, controlled crossover, dietary intervention study. Setting: The study was conducted at the Centre for Diabetes, Endocrinology, and Research, Royal Surrey County Hospital, Guildford, United Kingdom. Participants: Fifteen men and women with insulin resistance participated in the study. Intervention: The intervention included 40 g/d HAM-RS2 compared with a matched placebo for 8 wk. Main Outcome Measures: After each supplement, participants underwent a two-step hyperinsulinemic- euglycemic clamp study with the addition of glucose tracers; a meal tolerance test; arteriovenous sampling across forearm muscle tissue; and a sc adipose tissue biopsy for assessment of gene expression. Results: There was enhanced uptake of glucose into the forearm muscle measured by arteriovenous sampling (65 + 15% increase after resistant starch; P < 0.001). Adipose tissue function was also affected, with enhanced fatty acid suppression after HAM-RS2 treatment and an increase in gene expression for hormone sensitive lipase (P = 0.005), perilipin (P = 0.011), lipoprotein lipase (P = 0.014), and adipose triglyceride lipase (P = 0.03) in biopsy samples. There was no effect on the insulin sensitivity of hepatic glucose production or plasma lipids after HAM-RS2. Conclusion: HAM-RS2 improved peripheral but not hepatic insulin resistance and requires further study as an intervention in patients with or at risk for type 2 diabetes. Copyright 2012 by The Endocrine Society.

Author-supplied keywords

  • *adipose tissue
  • *dietary fiber
  • *food intake
  • *high amylose maize resistant starch type 2
  • *insulin sensitivity
  • *metabolic syndrome X/th [Therapy]
  • *muscle tissue
  • *starch
  • United Kingdom
  • adult
  • aged
  • article
  • biopsy
  • controlled study
  • crossover procedure
  • diet supplementation
  • fatty acid metabolism
  • female
  • food composition
  • forearm
  • gluconeogenesis
  • glucose tolerance test
  • glucose transport
  • high risk patient
  • hormone sensitive lipase/ec [Endogenous Compound]
  • human
  • human tissue
  • hyperinsulinemia
  • insulin resistance
  • lipid blood level
  • lipoprotein lipase/ec [Endogenous Compound]
  • male
  • non insulin dependent diabetes mellitus
  • perilipin/ec [Endogenous Compound]
  • placebo
  • priority journal
  • protein expression
  • randomization
  • randomized controlled trial
  • therapy effect
  • triacylglycerol lipase/ec [Endogenous Compound]
  • unclassified drug

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Authors

  • Robertson M.D.

  • Wright J.W.

  • Loizon E.

  • Debard C.

  • Vidal H.

  • Shojaee-Moradie F.

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