Integrin activation takes shape

  • Liddington R
  • Ginsberg M
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Integrins are cell surface adhesion receptors that are essential for the development and function of multicellular animals. Here we summarize recent findings on the regulation of integrin affinity for ligand (activation), one mechanism by which cells modulate integrin function. The focus is on the structural basis of integrin activation, the role of the cytoplasmic domain in integrin affinity regulation, and potential mechanisms by which activation signals are propagated from integrin cytoplasmic domains to the extracellular ligand-binding domain

Author-supplied keywords

  • Animal
  • Animals
  • Binding Sites
  • Cell Adhesion
  • Human
  • Integrins
  • Models,Molecular
  • Phosphotyrosine
  • Protein Conformation
  • Signal Transduction
  • Structure-Activity Relationship
  • Support,U.S.Gov't,P.H.S.
  • chemistry
  • metabolism

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links


  • R C Liddington

  • M H Ginsberg

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free