Integrins and cadherins as therapeutic targets in fibrosis

  • Agarwal S
  • 59


    Mendeley users who have this article in their library.
  • 21


    Citations of this article.


Fibrosis is the excessive deposition of extracellular matrix proteins into tissues leading to scar formation, disruption of normal tissue architecture and organ failure. Despite the large clinical impact of fibrosis, treatment options are limited. Adhesion molecules, in particular αvβ6 and α3β1 integrins and cadherin-11, have been demonstrated to be important mediators of tissue fibrosis. These data are reviewed here and provide the foundation for these molecules to be potential therapeutic targets for patients with fibrotic diseases.

Author-supplied keywords

  • Cadherins
  • Epithelial cells
  • Fibroblasts
  • Fibrosis
  • Integrins
  • Macrophage

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Sandeep K. Agarwal

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free