Intensity-modulated radiotherapy for laryngeal and hypopharyngeal cancer: Minimization of late dysphagia without jeopardizing tumor control [Intensitätsmodulierte Strahlentherapie von Plattenepithelkarzinomen des Kehlkopfes und Hypopharynx: Verringerung d

  • Modesto A
  • Laprie A
  • Vieillevigne L
 et al. 
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Purpose: The purpose of this work was to retrospectively determine the value of intensity-modulated radiotherapy (IMRT) in patients with laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC), on outcome and treatment-related toxicity compared to 3-dimensional conformal radiotherapy (3D-CRT). Materials and methods: A total of 175 consecutive patients were treated between 2007 and 2012 at our institution with curative intent RT and were included in this study: 90 were treated with 3D-CRT and 85 with IMRT. Oncologic outcomes were estimated using Kaplan–Meier statistics; acute and late toxicities were scored according to the Common Toxicity Criteria for Adverse Events scale v 3.0. Results: Median follow-up was 35 months (range 32–42 months; 95% confidence interval 95 %). Two-year disease-free survival did not vary, regardless of the technique used (69 % for 3D-CRT vs. 72 %; for IMRT, p = 0.16). Variables evaluated as severe late toxicities were all statistically lower with IMRT compared with 3D-CRT: xerostomia (0 vs. 12 %; p < 0.0001), dysphagia (4 vs. 26 %; p < 0.0001), and feeding-tube dependency (1 vs 13 %; p = 0.0044). The rates of overall grade ≥ 3 late toxicities for the IMRT and 3D-CRT groups were 4.1 vs. 41.4 %, respectively (p < 0.0001). Conclusion: IMRT for laryngeal and hypopharyngeal cancer minimizes late dysphagia without jeopardizing tumor control and outcome. © 2014, Springer-Verlag Berlin Heidelberg.

Author-supplied keywords

  • 80 and over; Carcinoma
  • Adjuvant; Radiotherapy
  • Adult; Aged; Aged
  • Intensity-Modulated; Retrospective Studies
  • Squamous Cell; Combined Modality Therapy; Degluti
  • Squamous Cell; Deglutition Disorders; Hypopharyng
  • adult; aged; Article; cancer control; cancer patie

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  • A Modesto

  • A Laprie

  • L Vieillevigne

  • P Graff

  • J Sarini

  • S Vergez

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