Intensity-modulated radiotherapy for laryngeal and hypopharyngeal cancer : Minimization of late dysphagia without jeopardizing tumor control.

  • Modesto A
  • Laprie A
  • Vieillevigne L
  • et al.
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Abstract

PURPOSE: The purpose of this work was to retrospectively determine the value of intensity-modulated radiotherapy (IMRT) in patients with laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC), on outcome and treatment-related toxicity compared to 3-dimensional conformal radiotherapy (3D-CRT). MATERIALS AND METHODS: A total of 175 consecutive patients were treated between 2007 and 2012 at our institution with curative intent RT and were included in this study: 90 were treated with 3D-CRT and 85 with IMRT. Oncologic outcomes were estimated using Kaplan-Meier statistics; acute and late toxicities were scored according to the Common Toxicity Criteria for Adverse Events scale v 3.0. RESULTS: Median follow-up was 35 months (range 32-42 months; 95% confidence interval 95 %). Two-year disease-free survival did not vary, regardless of the technique used (69 % for 3D-CRT vs. 72 %; for IMRT, p = 0.16). Variables evaluated as severe late toxicities were all statistically lower with IMRT compared with 3D-CRT: xerostomia (0 vs. 12 %; p < 0.0001), dysphagia (4 vs. 26 %; p < 0.0001), and feeding-tube dependency (1 vs 13 %; p = 0.0044). The rates of overall grade ≥ 3 late toxicities for the IMRT and 3D-CRT groups were 4.1 vs. 41.4 %, respectively (p < 0.0001). CONCLUSION: IMRT for laryngeal and hypopharyngeal cancer minimizes late dysphagia without jeopardizing tumor control and outcome.

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Modesto, A., Laprie, A., Vieillevigne, L., Graff, P., Sarini, J., Vergez, S., … Rives, M. (2014). Intensity-modulated radiotherapy for laryngeal and hypopharyngeal cancer : Minimization of late dysphagia without jeopardizing tumor control. Strahlentherapie Und Onkologie, 191(3), 225–233. https://doi.org/10.1007/s00066-014-0767-1

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