Inter- and intra-hemispheric EEG coherence in patients with mild cognitive impairment at rest and during working memory task

  • Jiang Z
  • Zheng L
  • 3

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Abstract

OBJECTIVE: To assess functional relationship by calculating inter- and intra-hemispheric electroencephalography (EEG) coherence at rest and during a working memory task of patients with mild cognitive impairment (MCI). METHODS: The sample consisted of 69 subjects: 35 patients (n=17 males, n=18 females; 52-71 years old) and 34 normal controls (n=17 males, n=17 females; 51~63 years old). Mini-mental state examination (MMSE) of two groups revealed that the scores of MCI patients did not differ significantly from those of normal controls (P>0.05). In EEG recording, subjects were performed at rest and during working memory task. EEG signals from F3-F4, C3-C4, P3-P4, T5-T6 and O1-O2 electrode pairs are resulted from the inter-hemispheric action, and EEG signals from F3-C3, F4-C4, C3-P3, C4-P4, P3-O1, P4-O2, T5-C3, T6-C4, T5-P3 and T6-P4 electrode pairs are resulted from the intra-hemispheric action for delta (1.0-3.5 Hz), theta (4.0-7.5 Hz), alpha-1 (8.0-10.0 Hz), alpha-2 (10.5-13.0 Hz), beta-1 (13.5-18.0 Hz) and beta-2 (18.5-30.0 Hz) frequency bands. The influence of inter- and intra-hemispheric coherence on EEG activity with eyes closed was examined using fast Fourier transformation from the 16 sampled channels. RESULTS: During working memory tasks, the inter- and intra-hemispheric EEG coherences in all bands were significantly higher in the MCI group in comparison with those in the control group (P

Author-supplied keywords

  • Aged
  • Cognition Disorders/*physiopathology
  • Electrodes
  • Electroencephalography
  • Female
  • Humans
  • Male
  • Memory/*physiology
  • Middle Aged
  • Rest/*physiology

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Authors

  • Z Y Jiang

  • L L Zheng

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