Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD

  • Viikki M
  • Huuhka K
  • Leinonen E
 et al. 
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Abstract

The 5HT2A receptor gene (HTR2A) polymorphisms rs7997012 and rs6311 have in some earlier studies been associated with serotonin selective reuptake inhibitor (SSRI) treatment response in major depressive disorder (MDD), but the findings are inconsistent. The aim of the present study was to test for an association between two HTR2A polymorphisms (rs7997012 and rs6311), their interaction and the Montgomery and Åsberg Depression Rating Scale (MADRS) score change after ECT or SSRI treatment. The total number of patients was 218. All were treated in outpatient care. Of these, 119 subjects had treatment-resistant MDD and were treated with ECT and 99 were depressive patients treated with SSRI. Treatment response was assessed by MADRS. Patients scoring

Author-supplied keywords

  • -102T/C
  • -1438A/G
  • 5HT2A
  • ECT
  • Gene polymorphism
  • MADRS score change
  • Mood disorders
  • Pharmacogenetics
  • Rs6311
  • Rs7997012
  • Treatment-resistant depression

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Authors

  • Merja Viikki

  • Kaija Huuhka

  • Esa Leinonen

  • Ari Illi

  • Eija Setälä-Soikkeli

  • Martti Huuhka

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