Interaction of cells and nanofiber scaffolds in tissue engineering

  • Venugopal J
  • Low S
  • Choon A
 et al. 
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Abstract

Nanofibers and nanomaterials are potentially recent additions to materials in relation to tissue engineering (TE). TE is the regeneration of biological tissues through the use of cells, with the aid of supporting structures and biomolecules. Mimicking architecture of extracellular matrix is one of the challenges for TE. Biodegradable biopolymer nanofibers with controlled surface and internal molecular structures can be electrospun into mats with specific fiber arrangement and structural integrity for drug delivery and TE applications. The polymeric materials are widely accepted because of their ease of processability and amenability to provide a large variety of cost-effective materials, which help to enhance the comfort and quality of life in modern biomedical and industrial society. Today, nanotechnology and nanoscience approaches to scaffold design and functionalization are beginning to expand the market for drug delivery and TE is forming the basis for highly profitable niche within the industry. This review describes recent advances for fabrication of nanofiber scaffolds and interaction of cells in TE. � 2007 Wiley Periodicals, Inc.

Author-supplied keywords

  • Animals
  • Bandages
  • Biocomposite
  • Biodegradable biopolymer nanofibers
  • Biodegradable polymers
  • Biomolecules
  • Blood Vessels
  • Bone and Bones
  • Cells
  • Delayed-Action Preparations
  • Electrospinning
  • Humans
  • Mimicking architecture
  • Nanofiber scaffolds
  • Nanofibers
  • Nanotubes
  • Polymers
  • Porosity
  • Skin
  • Tissue Engineering
  • Tissue Scaffolds
  • Tissue culture
  • antibiotic agent
  • article
  • biocompatibility
  • biodegradability
  • biomaterial
  • biopolymer
  • blood vessel graft
  • bone
  • cartilage
  • cefoxitin
  • cell interaction
  • ceramics
  • chitosan
  • ciprofloxacin
  • clonazepam
  • collagen
  • controlled drug release
  • coronary artery bypass graft
  • cost effectiveness analysis
  • drug carrier
  • drug delivery system
  • endothelium cell
  • extracellular matrix
  • fatty acid
  • fibrinogen
  • fibroblast
  • fibroin
  • gelatin
  • hydrogel
  • hydrophilicity
  • hydrophobicity
  • hydroxyapatite
  • itraconazole
  • ketanserin
  • methacrylic acid derivative
  • nanofiber
  • nanotechnology
  • nerve graft
  • nerve growth factor
  • nerve regeneration
  • paclitaxel
  • particle size
  • polyglycolic acid
  • polylactic acid
  • polymer
  • rifampicin
  • technology
  • thickness
  • tobramycin
  • viscosity
  • water
  • wound healing

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Authors

  • J Venugopal

  • S Low

  • A T Choon

  • Seeram Ramakrishna

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