Interactive Effects of a DRD4 Polymorphism, Lead, and Sex on Executive Functions in Children

  • Froehlich T
  • Lanphear B
  • Dietrich K
 et al. 
  • 63


    Mendeley users who have this article in their library.
  • 52


    Citations of this article.


Background: Prior studies have examined independent effects of a dopamine receptor D4 polymorphism (DRD4-7) and lead exposure on executive functions but not their interaction or the role of sex as a modifier of their effects. Methods: Multivariable analyses were used to examine effects of DRD4-7 genotype, 60-month blood lead level, and sex on spatial working memory, rule learning and reversal, spatial span, and planning for 174 children. Results: DRD4-7 was associated with poorer spatial working memory, and increasing blood lead levels were associated with impaired rule learning and reversal, spatial span, and planning. Adverse effects of lead on planning and rule learning and reversal were seen primarily for boys. In addition, the effect of lead on rule learning and reversal was evident predominately for those lacking DRD4-7. Conclusions: We observed independent effects of DRD4-7 and lead on various executive functions and modifications of lead effects by DRD4 genotype and sex. © 2007 Society of Biological Psychiatry.

Author-supplied keywords

  • Dopamine genes
  • dopamine receptor D4/DRD4
  • executive function
  • gene-environment interaction
  • lead
  • sex/gender

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free