Intermittent hypoxic training: implications for lipid peroxidation induced by acute normoxic exercise in active men.

  • Bailey D
  • Davies B
  • Young I
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Abstract

Oxidant generation during regular physical exercise training may influence the adaptive responses that have been shown to confer protection against oxidative stress induced by subsequent acute exercise. To examine this, we randomly assigned 32 males to either a normoxic (n=14) or a hypoxic (n=18) group. During the acute phase, subjects in the hypoxic group performed two maximal cycling tests in a randomized double-blind fashion: one under conditions of normoxia and the other under hypoxic conditions (inspired fraction of O(2)=0.21 and 0.16 respectively). During the intermittent phase, the normoxic and hypoxic groups each trained for 4 weeks at the same relative exercise intensity, under conditions of normoxia and hypoxia respectively. During acute exercise under hypoxic conditions, the venous concentrations of lipid hydroperoxides and malondialdehyde were increased, despite a comparatively lower maximal oxygen uptake (VO(2max)) (P

Author-supplied keywords

  • Adult
  • Analysis of Variance
  • Anoxia
  • Anoxia: metabolism
  • Antioxidants
  • Antioxidants: analysis
  • Chromatography, High Pressure Liquid
  • Chromatography, High Pressure Liquid: methods
  • Double-Blind Method
  • Exercise
  • Exercise Test
  • Exercise: physiology
  • Fatty Acids, Nonesterified
  • Fatty Acids, Nonesterified: blood
  • Humans
  • Lipid Peroxidation
  • Lipid Peroxidation: physiology
  • Lipid Peroxides
  • Lipid Peroxides: blood
  • Male
  • Malondialdehyde
  • Malondialdehyde: blood
  • Normal Distribution

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Authors

  • D M Bailey

  • B Davies

  • I S Young

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