Journal article

Interrelationships of transcriptional machinery with nuclear architecture

Stein G, van Wijnen A, Stein J, Lian J ...see all

Crit Rev Eukaryot Gene Expr, vol. 9, issue 3-4 (1999) pp. 183-190

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There is increasing evidence for functional linkages between nuclear architecture and the regulation of gene expression. The nuclear matrix provides a paradigm for involvement of nuclear morphology in assembly of the biochemical machinery for physiological control of transcription. Mechanisms are being experimentally defined that direct regulatory factors to subnuclear sites that support gene expression. Consequently, we are gaining insight into the rules that govern transcriptional control within the three-dimensional context of nuclear organization.

Author-supplied keywords

  • *Gene Expression Regulation
  • *Transcription, Genetic
  • Animals
  • Cell Nucleus/chemistry/*genetics/ultrastructure
  • Chromatin/chemistry/genetics/ultrastructure
  • Humans
  • Nuclear Matrix/chemistry/genetics/ultrastructure
  • Research Support, U.S. Gov't, P.H.S.

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  • PMID: 10651235
  • SGR: 0033370816
  • SCOPUS: 2-s2.0-0033370816
  • PUI: 30053871
  • ISSN: 10454403


  • G S Stein

  • A J van Wijnen

  • J L Stein

  • J B Lian

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