The intracellular domain of Notch ligand Delta1 induces cell growth arrest

  • Kolev V
  • Kacer D
  • Trifonova R
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Notch signaling involves proteolytic cleavage of the transmembrane Notch receptor after binding to its transmembrane ligands, Delta or Jagged; and the resultant soluble intracellular domain of Notch stimulates a cascade of transcriptional events. The Delta1 ligand also undergoes proteolytic cleavage upon Notch binding, resulting in the production of a free intracellular domain. We demonstrate that the expression of the intracellular domain of Delta1 results in a non-proliferating senescent-like cell phenotype which is dependent on the expression of the cell cycle inhibitor, p21, and is abolished by co-expression of constitutively active Notch1. These data suggest a new intracellular role for Delta1.

Author-supplied keywords

  • *Cell Proliferation
  • Animals
  • Cell Aging
  • Humans
  • Ligands
  • Membrane Proteins/chemistry/genetics/*metabolism
  • Mice
  • NIH 3T3 Cells
  • Protein Structure, Tertiary
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links


  • V Kolev

  • D Kacer

  • R Trifonova

  • D Small

  • M Duarte

  • R Soldi

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free