Notch signaling involves proteolytic cleavage of the transmembrane Notch receptor after binding to its transmembrane ligands, Delta or Jagged; and the resultant soluble intracellular domain of Notch stimulates a cascade of transcriptional events. The Delta1 ligand also undergoes proteolytic cleavage upon Notch binding, resulting in the production of a free intracellular domain. We demonstrate that the expression of the intracellular domain of Delta1 results in a non-proliferating senescent-like cell phenotype which is dependent on the expression of the cell cycle inhibitor, p21, and is abolished by co-expression of constitutively active Notch1. These data suggest a new intracellular role for Delta1. © 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
CITATION STYLE
Kolev, V., Kacer, D., Trifonova, R., Small, D., Duarte, M., Soldi, R., … Prudovsky, I. (2005). The intracellular domain of Notch ligand Delta1 induces cell growth arrest. FEBS Letters, 579(25), 5798–5802. https://doi.org/10.1016/j.febslet.2005.09.042
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