Intraclonal competition limits regulatory T cell fate determination in the thymus

  • Bautista J
  • Lio C
  • Lathrop S
 et al. 
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Because the deletion of self-reactive T cells is incomplete, thymic development of natural Foxp3+CD4+ regulatory T (Treg) cells is required for preventing autoimmunity. However, the role of T cell receptor (TCR) specificity in thymic Treg cell development remains controversial. To address this issue, we generated a transgenic line expressing a naturally occurring Treg cell-derived TCR. Surprisingly, efficient thymic Treg cell development occurred only when the antigen-specific Treg cell precursors were present at low clonal frequency (

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  • Jhoanne L Bautista

  • Chan-wang J Lio

  • Stephanie K Lathrop

  • Katherine Forbush

  • Yuqiong Liang

  • Jingqin Luo

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