Intracranial hemorrhage in newborns with hemophilia: The role of screening radiologic studies in the first 7 days of life

  • Smith A
  • Leonard N
  • Kurth M
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Abstract

In newborns with hemophilia, intracranial hemorrhage (ICH) is a potentially life-threatening event and in those who survive, there is a risk of long-term neurologic sequelae. A single-center retrospective chart review was performed to look at the utility of central nervous system screening of babies who were diagnosed with moderate or severe hemophilia in the first 7 days of life. Twenty of the twenty-two eligible babies had either a head ultrasound or computerized tomography of the head performed as soon as possible after the diagnosis of hemophilia was confirmed. ICH was found in 3 of the 20 newborns. All patients with ICH had instrument-assisted deliveries with extracranial signs of bleeding/trauma. On the basis of this series we found screening to be safe and effective in recognizing ICH. As a result of this approach, all ICHs were found when they were radiographically small and before the babies had neurologic symptoms.

Author-supplied keywords

  • Head CT
  • Hemophilia
  • Intracranial hemorrhage
  • Newborn
  • Screening

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Authors

  • Angela R. Smith

  • Nicole Leonard

  • Margaret Heisel Kurth

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