Intraoperative monitoring of cerebral blood flow by laser speckle contrast analysis

  • N. H
  • J. W
  • J.P. D
 et al. 
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

OBJECT: Currently, reliable low-cost and noninvasive techniques to assess cerebral perfusion in the operating room are not available. The authors report on their first clinical experience with laser speckle contrast analysis (LASCA) as a complementary imaging tool for the noninvasive and dynamic assessment of cerebral blood flow (CBF) during neurovascular surgery. The purpose of this preliminary study was to address the general feasibility of LASCA in terms of handling and image quality and to provide an example of its clinical implications., METHODS: Laser speckle contrast analysis was performed in patients undergoing cerebral revascularization procedures for the treatment of hemodynamic compromise and complex aneurysms. The portable LASCA device was centered over the surgical field, and continuous 5-minute recordings of relative CBF were obtained. In the case of flow augmentation for hemodynamic compromise, CBF monitoring was performed before and after completion of the anastomosis. In the case of flow replacement for parent artery sacrifice, CBF monitoring was performed during consecutive 30-second test occlusions of the radial artery graft after proximal internal carotid artery sacrifice and the subsequent initiation of blood flow through the bypass., RESULTS: In all cases, the authors achieved good visualization of relative CBF in addition to flow imaging in both the bypass graft and the cortical vasculature. During a sudden CBF decrease after test occlusion of the radial artery graft and subsequent flow initiation through the bypass, LASCA allowed immediate visualization and measurement of relative CBF in excellent spatiotemporal resolution., CONCLUSIONS: In this study LASCA offered noninvasive and rapid intraoperative assessment of relative CBF, which can be used for optimizing neurovascular procedures.

Author-supplied keywords

  • *Cerebral Revascularization/mt [Methods]
  • *Cerebrovascular Circulation/ph [Physiology]
  • *Cerebrovascular Disorders/su [Surgery]
  • *Lasers
  • *Monitoring
  • *brain circulation
  • *cerebral revascularization
  • *cerebrovascular disease/di [Diagnosis]
  • *cerebrovascular disease/su [Surgery]
  • *laser
  • *patient monitoring
  • Adult
  • Aged
  • Anastomosis
  • Blood Flow Velocity/ph [Physiology]
  • Cerebral Cortex/bs [Blood Supply]
  • Cerebrovascular Disorders/di [Diagnosis]
  • Computer-Assisted
  • Feasibility Studies
  • Female
  • Humans
  • Image Enhancement
  • Image Interpretation
  • Intracranial Aneurysm/di [Diagnosis]
  • Intracranial Aneurysm/su [Surgery]
  • Intraoperative/mt [Methods]
  • Laser-Doppler Flowmetry/mt [Methods]
  • Male
  • Middle Aged
  • Radial Artery/tr [Transplantation]
  • Surgical/mt [Methods]
  • Vascular Patency/ph [Physiology]
  • adult
  • aged
  • anastomosis
  • article
  • blood flow velocity
  • brain cortex
  • computer assisted diagnosis
  • diagnostic agent
  • feasibility study
  • female
  • human
  • image enhancement
  • intracranial aneurysm/di [Diagnosis]
  • intracranial aneurysm/su [Surgery]
  • laser Doppler flowmetry
  • male
  • methodology
  • middle aged
  • physiology
  • radial artery
  • transplantation
  • vascular patency
  • vascularization

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Hecht N.

  • Woitzik J.

  • Dreier J.P.

  • Nils Hecht

  • Johannes Woitzik

  • Jens P Dreier

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free