Intravenous fosphenytoin in acute mania

  • Applebaum J
  • Levine J
  • Belmaker R
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Since several anticonvulsants are therapeutic in mania and since acute mania requires rapid and intensive treatment, we hypothesized that intravenous high-dose phenytoin might be acutely antimanic. A new prodrug of phenytoin, fosphenytoin, which has few cardiac or local vein side effects, was used to test this hypothesis.

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  • Julia Applebaum

  • Joseph Levine

  • R. H. Belmaker

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