Intrinsic Dissolution Rates of Tablet Filler-Binders and Their Influence on the Dissolution of Drugs from Tablet Formulations

  • Koparkar A
  • Augsburger L
  • Shangraw R
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Abstract

Intrinsic dissolution rates were determined for different grades of commonly used calcium salt fillers and lactose. Typical tablet formulations of low-dose drugs were studied to determined the influence of this property on drug dissolution.

Author-supplied keywords

  • calcium salt
  • drug dissolution
  • intrinsic dissolution rate
  • lactose
  • rotating disk method
  • tablet filler

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Authors

  • Arun D. Koparkar

  • Larry L. Augsburger

  • Ralph F. Shangraw

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