An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample

  • Bogl L
  • Latvala A
  • Kaprio J
 et al. 
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Abstract

Abstract The purpose of this study was to investigate the relationship of fat mass (FM) and lean mass (LM) with bone mineral density (BMD) independent of genetic effects. We also assessed the extent to which genetic and environmental influences explain the associations between these phenotypes. Body composition and BMD were measured using dual-energy X-ray absorptiometry in 57 monozygotic and 92 same-sex dizygotic twin pairs, aged 23 to 31 years, chosen to represent a wide range of intrapair differences in body mass index (BMI; 0 to 15.2 kg/m2). Heritability estimates were adjusted for height and gender. In multiple linear regression analysis, intrapair differences in both FM and LM were independently associated with intrapair differences in BMD at most skeletal sites after adjustment for gender and differences in height. Within monozygotic and dizygotic pairs, LM was a significantly stronger predictor of whole-body BMD than FM (p 

Author-supplied keywords

  • BONE MINERAL DENSITY
  • FAT MASS
  • GENETIC CORRELATION
  • LEAN MASS
  • TWIN STUDIES

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Authors

  • Leonie H. Bogl

  • Jaakko Kaprio

  • Olli Sovijärvi

  • Aila Rissanen

  • Kirsi H. Pietiläinen

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