Iodine-123 metaiodobenzylguanidine imaging and carbon-11 hydroxyephedrine positron emission tomography compared in patients with left ventricular dysfunction

  • Matsunari I
  • Aoki H
  • Nomura Y
 et al. 
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Abstract

Background-Although both (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging and (11)C-hydroxyephedrine ((11)C-HED) positron emission tomography (PET) are used for assessing cardiac sympathetic innervation, their relationship remains unknown. The aims were to determine whether (123)I-MIBG parameters such as heart-to-mediastinum ratio (H/M) are associated with quantitative measures by (11)C-HED PET and to compare image quality, defect size, and location between (123)I-MIBG single-photon emission computed tomography (SPECT) and (11)C-HED PET. Methods and Results-Twenty-one patients (mean left ventricular ejection fraction, 39 +/- 15%) underwent (123)I-MIBG imaging and (11)C-HED PET. Early (15-minute), late (3-hour) H/M, and washout rate (WR) were calculated for (123)I-MIBG. Myocardial retention and WR was calculated for (11)C-HED. Using a polar map approach, defect was defined as the area with relative activity

Author-supplied keywords

  • Nervous system
  • Radioisotopes
  • Sympathetic
  • Tomography

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Authors

  • Ichiro Matsunari

  • Hirofumi Aoki

  • Yusuke Nomura

  • Nozomi Takeda

  • Wei Ping Chen

  • Junichi Taki

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