Ion mobility spectrometry for the detection of volatile organic compounds in exhaled breath of patients with lung cancer: results of a pilot study.

  • Westhoff M
  • Litterst P
  • Freitag L
 et al. 
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Abstract

Analysis of exhaled breath, especially of volatile organic compounds (VOCs), is of increasing interest in the diagnosis of lung cancer. Compared with other methods of breath analysis, ion mobility spectrometry (IMS) offers a tenfold higher detection rate of VOCs. By coupling the ion mobility spectrometer with a multicapillary column as a pre-separation unit, IMS offers the advantage of an immediate twofold separation of VOCs with visualisation in a three-dimensional chromatogram. The total analysis time is about 500 s compared with gas chromatography/mass spectrometry (GC/MS) of about 1 h. It therefore seemed reasonable to test IMS in breath analysis.

Author-supplied keywords

  • Aged
  • Biological
  • Biological: analysis
  • Breath Tests
  • Breath Tests: instrumentation
  • Breath Tests: methods
  • Carcinoma
  • Carcinoma in Situ
  • Carcinoma in Situ: diagnosis
  • Epidemiologic Methods
  • Female
  • Humans
  • Ions
  • Ions: analysis
  • Lung Neoplasms
  • Lung Neoplasms: diagnosis
  • Male
  • Mass Spectrometry
  • Mass Spectrometry: instrumentation
  • Mass Spectrometry: methods
  • Middle Aged
  • Non-Small-Cell Lung
  • Non-Small-Cell Lung: diagnosis
  • Pilot Projects
  • Small Cell Lung Carcinoma
  • Small Cell Lung Carcinoma: diagnosis
  • Tumor Markers
  • Volatile Organic Compounds
  • Volatile Organic Compounds: analysis

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Authors

  • Michael Westhoff

  • Patrick Litterst

  • Lutz Freitag

  • W Urfer

  • Sabine Bader

  • Jörg Ingo Baumbach

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