Ionic Mechanisms of Cellular Electrical and Mechanical Abnormalities in Brugada Syndrome

  • Dong M
  • Niklewski P
  • Wang H
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The Brugada syndrome (BrS) is a right ventricular (RV) arrhythmia that is responsible for up to 12% of sudden cardiac deaths. The aims of our study were to determine the cellular mechanisms of the electrical abnormality in BrS and the potential basis of the RV contractile abnormality observed in the syndrome. Tetrodotoxin was used to reduce cardiac Na(+) current (I(Na)) to mimic a BrS-like setting in canine ventricular myocytes. Moderate reduction (

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  • Min Dong

  • Paul Niklewski

  • Hong-Sheng Wang

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