IQGAP1 and Its Binding Proteins Control Diverse Biological Functions.

  • White C
  • Erdemir H
  • Sacks D
  • 6


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


IQGAP proteins have been identified in a wide spectrum of organisms, ranging from yeast to humans. The most extensively studied family member is the ubiquitously expressed scaffold protein IQGAP1, which participates in multiple essential aspects of mammalian biology. IQGAP1 mediates these effects by binding to and regulating the function of numerous interacting proteins. Over ninety proteins have been reported to associate with IQGAP1, either directly or as part of a larger complex. In this review, we summarise those IQGAP1 binding partners that have been identified in the last five years. The molecular mechanisms by which these interactions contribute to the functions of receptors and their signalling cascades, small GTPase function, cytoskeletal dynamics, neuronal regulation and intracellular trafficking are evaluated. The evidence that has accumulated recently validates the role of IQGAP1 as a scaffold protein and expands the repertoire of cellular activities in which it participates. © 2011.

Author-supplied keywords

  • 1
  • cell signalling
  • fish
  • including yeast
  • iqgap
  • iqgap1
  • numerous organisms
  • proteins is found in
  • scaffold protein
  • the iqgap family of
  • the iqgap protein family

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • CD White

  • HH Erdemir

  • DB Sacks

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free