Isolasi dan karakterisasi senyawa metabolit sekunder dari bakteri laut Streptomyces sp. Isolation and characterization of secondary metabolites from marine bacterium Streptomyces sp

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Abstract

Streptomyces is one of bacterial genus which has been considered as a potential source of many novel antibiotics from both terrestrial and marine microorganism. In this paper, four secondary metabolites have been isolated and characterized from a marine Streptomyces sp. B5798, namely p-hydroxyphenylacetic acid (2), indole-3-carboxylic acid (3), indole-3-acetic acid (4), and Macrolactin A (5), respectively. Two of them are common compounds, namely indole-3-carboxylic acid (3) and indole-3-acetic acid (4). The 3,4-dihydroxybenzaldehyde is a degradation product of p-hydroxyphenylacetic (2) in microorganism. Macrolactin A (5) showed cytotoxicity against brine shrimps test (A. salina). All structures of the isolated compounds were elucidated based on spectroscopic and mass spectrometry data. Abstrak: Streptomyces merupakan salah satu genus dalam kelas bakteri yang banyak terdapat baik di daratan maupun di lautan. Genus Streptomyces ini sangat potensial sebagai sumber bahan antibiotika yang berasal dari mikroorganisme. Dalam penelitian ini, sebanyak empat senyawa metabolit sekunder telah berhasil diisolasi dan dikarakterisasi dari marine Streptomyces sp. B5798 yaitu asam p-hidroksifenilasetat (2), asam indole-3-karboksilat (3), asam indole-3-asetat (4), dan Macrolactin A (5). Dua diantaranya merupakan senyawa trivial yaitu asam indole-3-karboksilat (3) dan asam indole-3-asetat (4). Asam p-hidroksifenilasetat (2) merupakan produk degradasi dari 3,4-dihidroksibenzaldehid pada mikroorgamisme yang merupakan prekursor dari obat anti-Parkinson. Macrolactin A (5) menunjukkan aktivitas sitotoksik terhadap A. Salina. Elusidasi struktur senyawa hasil isolasi ditentukan berdasarkan data spektroskopi dan spektrometri massa. Kata kunci: Streptomyces, laut, senyawa metabolit sekunder, antibiotika

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Bahi, M. (2012). Isolasi dan karakterisasi senyawa metabolit sekunder dari bakteri laut Streptomyces sp. Isolation and characterization of secondary metabolites from marine bacterium Streptomyces sp. Depik Universitas Syiah Kuala, 1(3), 159–162.

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