Cryptophycin-38 (2), -326 (3), and -327 (4) are three new trace constituents of the terrestrial cyanobacterium Nostoc sp. GSV 224. Cryptophycin-38 is a stereoisomer of cryptophycin-1 (1) and to date is the only naturally occurring analogue that possesses a S,S epoxide group in unit A. Cryptophycin-327 is a geometric isomer that differs from 1 in having a cis Δ2-double bond in unit A. Cryptophycin-326 is related to cryptophycin-21, but has two chlorines ortho to the methoxy group in unit B. The relative and absolute stereochemistries of 2 have been related to known cryptophycins by semisynthesis and/or spectral analysis.
CITATION STYLE
Chaganty, S., Golakoti, T., Heltzel, C., Moore, R. E., & Yoshida, W. Y. (2004). Isolation and structure determination of Cryptophycins 38, 326, and 327 from the terrestrial Cyanobacterium Nostoc sp. GSV 224. Journal of Natural Products, 67(8), 1403–1406. https://doi.org/10.1021/np0499665
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