Isoxazole derivatives in the synthesis of bifunctional compounds by cleavage of the heteroring (review)

  • Akhrem A
  • Lakhvich F
  • Khripach V
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The pathways and methods of transformation of isoxazoles to give various acyclic difunctional derivatives (α-cyano ketones, β-diketones, imino and amino ketones, β-amino alcohols, α,β-unsaturated ketones, etc.) by opening of the heteroring are examined in the review from the point of view of latent functionality. The prospects for the application of acyclic functional derivatives of isoxazoles and 2-isoxazolines — adducts of 1,3-dipolar cycloaddition of nitrile oxides to olefins and acetylenes — for regio- and stereospecific synthesis are discussed

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  • A. A. Akhrem

  • F. A. Lakhvich

  • V. A. Khripach

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