KAJIAN INTERAKSI ZAT BESI DENGAN ZAT GIZI MIKRO LAIN DALAM SUPLEMENTASI (REVIEW OF INTERACTIONS BETWEEN IRON AND OTHER MICRONUTRIENTS IN SUPPLEMENTATION)

Abstract

Micronutrients play a necessary and important role in the metabolism. One way to improve micronutrient deficiency condition is by supplementing these nutrients, both single or in combination. The impact of nutritional supplementation with a combination of two substances is the interaction of the nutrients, either synergistic or antagonistic. Some interactions of iron with other micronutrients, such as the iron with zinc, vitamin A, copper and vitamin C that are commonly found in several studies shows that iron supplementation with zinc causes a synergistic effect when they are given along with food and drink. However, iron and zinc complete each other if they are given only with drinks. Supplementation of iron combined with vitamin A produce a synergistic Interaction. This supplementation can increase the levels of iron and vitamin A simultaneously. Iron and copper can not be given in combination because they compete in the process of absorption in the intestine. The combine supplementation of iron and vitamin C has a significant impact in increasing the iron status of anemia subjects. The supplementation of combine nutrition should consider the condition of the subject, food consumption, mode of administration and the absorption of these nutrients in the body.