Ketamine modulates theta and gamma oscillations

  • Lazarewicz M
  • Ehrlichman R
  • Maxwell C
 et al. 
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Abstract

■ Ketamine, an N-methyl-D-aspartate (NMDA) receptor gluta-matergic antagonist, has been studied as a model of schizophrenia when applied in subanesthetic doses. In EEG studies, ketamine affects sensory gating and alters the oscillatory characteristics of neuronal signals in a complex manner. We investigated the effects of ketamine on in vivo recordings from the CA3 region of mouse hippocampus referenced to the ipsilateral frontal sinus using a paired-click auditory gating paradigm. One issue of particular in-terest was elucidating the effect of ketamine on background net-work activity, poststimulus evoked and induced activity. We find that ketamine attenuates the theta frequency band in both back-ground activity and in poststimulus evoked activity. Ketamine also disrupts a late, poststimulus theta power reduction seen in control recordings. In the gamma frequency range, ketamine enhances both background and evoked power, but decreases relative induced power. These findings support a role for NMDA receptors in mediat-ing the balance between theta and gamma responses to sensory stim-uli, with possible implications for dysfunction in schizophrenia. ■

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Authors

  • Maciej T. Lazarewicz

  • Richard S. Ehrlichman

  • Christina R. Maxwell

  • Michael J. Gandal

  • Leif H. Finkel

  • Steven J. Siegel

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