Kidney NGAL is a novel early marker of acute injury following transplantation

  • Mishra J
  • Ma Q
  • Kelly C
 et al. 
  • 29

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Abstract

Acute kidney injury secondary to ischemia-reperfusion in renal allografts often results in delayed graft function. We tested the hypothesis that expression of neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of acute kidney injury following transplantation. Sections from paraffin-embedded protocol biopsy specimens obtained at approximately one hour of reperfusion after transplantation of 13 cadaveric (CAD) and 12 living-related (LRD) renal allografts were examined by immunohistochemistry for expression of NGAL. The staining intensity was correlated with cold ischemia time, peak post-operative serum creatinine, and dialysis requirement. There were no differences between the LRD and CAD groups in age, gender or preoperative serum creatinine. Using a scoring system of 0 (no staining) to 3 (most intense staining), NGAL expression was significantly increased in CAD specimens (2.3+/-0.8 versus 0.8+/-0.7 in LRD, p

Author-supplied keywords

  • *Kidney Transplantation
  • Acute-Phase Proteins/*analysis
  • Adolescent
  • Adult
  • Biological Markers/analysis
  • Cadaver
  • Child
  • Delayed Graft Function/*diagnosis/pathology
  • Female
  • Humans
  • Kidney Failure, Acute/*diagnosis/pathology
  • Kidney/*chemistry/pathology
  • Lipocalins
  • Living Donors
  • Male
  • Prognosis
  • Proto-Oncogene Proteins/*analysis
  • Reperfusion Injury/*diagnosis/pathology
  • Tissue Donors

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Authors

  • J Mishra

  • Q Ma

  • C Kelly

  • M Mitsnefes

  • K Mori

  • J Barasch

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