Kinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke

  • Fridman E
  • Crespo M
  • Argüello S
 et al. 
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Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.

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  • Esteban FridmanJoan and Sanford I Weill Medical College of Cornell University

  • Marcos CrespoFundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia

  • Santiago Gomez Argüello

  • Lorena Degue

  • Mirta Villarreal

  • Stephan Bohlhalter

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