Large-scale neural ensemble recording in the brains of freely behaving mice

  • Lin L
  • Chen G
  • Xie K
 et al. 
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With the availability of sophisticated genetic techniques, the mouse is a valuable mammalian model to study the molecular and cellular basis of cognitive behaviors. However, the small size of mice makes it difficult for a systematic investigation of activity patterns of neural networks in vivo. Here we report the development and construction of a high-density ensemble recording array with up to 128-recording channels that can be formatted as single electrodes, stereotrodes, or tetrodes. This high-density recording array is capable of recording from hundreds of individual neurons simultaneously in the hippocampus of the freely behaving mice. This large-scale in vivo ensemble recording techniques, once coupled with mouse genetics, should be valuable to the study of complex relationship between the genes, neural network, and cognitive behaviors. © 2006 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • CA1 region
  • Ensemble recording
  • Hippocampus
  • In vivo recording
  • Memory
  • Microdrive
  • Mouse
  • Startle
  • Stereotrode
  • Tetrode

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  • Longnian Lin

  • Guifen Chen

  • Kun Xie

  • Kimberly A. Zaia

  • Shuqing Zhang

  • Joe Z. Tsien

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