Late effects in adult survivors of childhood cancer: Considerations for the general practitioner

  • D. S
  • L. A
  • K. B
 et al. 
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Childhood cancer survivorship is a national public health priority, with an increasing number of survivors who face late effects from both disease and treatment. As childhood cancer survivors are living into adulthood, care of the late effects associated with their diagnosis and treatment can become complex. Often these patients no longer have follow-up with the treating pediatric hospital and seek medical care from an adult primary care professional. Combining the results of current survivorship research with clinical experience, we describe common late effects that general internists and primary care professionals may encounter during routine visits with adult survivors of childhood cancer. Recommendations and resources are provided for identifying and managing late effects.

Author-supplied keywords

  • *cancer survival
  • *childhood cancer/dt [Drug Therapy]
  • *childhood cancer/rt [Radiotherapy]
  • article
  • attention deficit disorder/dt [Drug Therapy]
  • avascular necrosis/si [Side Effect]
  • bladder bleeding/si [Side Effect]
  • bleomycin/ae [Adverse Drug Reaction]
  • bleomycin/dt [Drug Therapy]
  • bone marrow suppression/si [Side Effect]
  • brain cancer/dt [Drug Therapy]
  • brain cancer/rt [Radiotherapy]
  • breast cancer/co [Complication]
  • busulfan/ae [Adverse Drug Reaction]
  • busulfan/dt [Drug Therapy]
  • cancer radiotherapy
  • carboplatin/ae [Adverse Drug Reaction]
  • carboplatin/dt [Drug Therapy]
  • carmustine/ae [Adverse Drug Reaction]
  • carmustine/dt [Drug Therapy]
  • child
  • chlormethine/ae [Adverse Drug Reaction]
  • chlormethine/dt [Drug Therapy]
  • cisplatin/ae [Adverse Drug Reaction]
  • cisplatin/dt [Drug Therapy]
  • cognitive defect/co [Complication]
  • cognitive defect/si [Side Effect]
  • cognitive defect/th [Therapy]
  • cognitive therapy
  • cyclophosphamide/ae [Adverse Drug Reaction]
  • cyclophosphamide/dt [Drug Therapy]
  • cytarabine/ae [Adverse Drug Reaction]
  • cytarabine/dt [Drug Therapy]
  • dacarbazine/ae [Adverse Drug Reaction]
  • dacarbazine/dt [Drug Therapy]
  • daunorubicin/ae [Adverse Drug Reaction]
  • daunorubicin/dt [Drug Therapy]
  • dexamethasone/ae [Adverse Drug Reaction]
  • dexamethasone/dt [Drug Therapy]
  • doxorubicin/ae [Adverse Drug Reaction]
  • doxorubicin/dt [Drug Therapy]
  • early menopause/si [Side Effect]
  • endocrine disease/co [Complication]
  • etoposide/ae [Adverse Drug Reaction]
  • etoposide/dt [Drug Therapy]
  • exercise
  • fluorouracil/ae [Adverse Drug Reaction]
  • fluorouracil/dt [Drug Therapy]
  • follow up
  • general practitioner
  • germ cell tumor/dt [Drug Therapy]
  • gonad dysfunction/si [Side Effect]
  • health care personnel
  • hearing loss/si [Side Effect]
  • heart disease/si [Side Effect]
  • human
  • ifosfamide/ae [Adverse Drug Reaction]
  • ifosfamide/dt [Drug Therapy]
  • infertility/co [Complication]
  • infertility/si [Side Effect]
  • kidney dysfunction/si [Side Effect]
  • leukemia/dt [Drug Therapy]
  • leukemia/rt [Radiotherapy]
  • leukemia/si [Side Effect]
  • liver cancer/dt [Drug Therapy]
  • liver fibrosis/si [Side Effect]
  • liver tumor/dt [Drug Therapy]
  • lomustine/ae [Adverse Drug Reaction]
  • lomustine/dt [Drug Therapy]
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  • lung injury/si [Side Effect]
  • lymphoma/dt [Drug Therapy]
  • lymphoma/rt [Radiotherapy]
  • malignant neoplastic disease/si [Side Effect]
  • melphalan/ae [Adverse Drug Reaction]
  • melphalan/dt [Drug Therapy]
  • mercaptopurine/ae [Adverse Drug Reaction]
  • mercaptopurine/dt [Drug Therapy]
  • metabolic syndrome X/si [Side Effect]
  • metastasis/si [Side Effect]
  • methotrexate/ae [Adverse Drug Reaction]
  • methotrexate/dt [Drug Therapy]
  • methotrexate/tl [Intrathecal Drug Administration]
  • methylphenidate/dt [Drug Therapy]
  • mitoxantrone/ae [Adverse Drug Reaction]
  • mitoxantrone/dt [Drug Therapy]
  • nephroblastoma/dt [Drug Therapy]
  • nephroblastoma/rt [Radiotherapy]
  • neuroblastoma/dt [Drug Therapy]
  • neuroblastoma/rt [Radiotherapy]
  • nutritional health
  • osteosarcoma/dt [Drug Therapy]
  • patient care
  • patient counseling
  • patient monitoring
  • pediatric hospital
  • prednisone/ae [Adverse Drug Reaction]
  • prednisone/dt [Drug Therapy]
  • premature labor/co [Complication]
  • primary medical care
  • procarbazine/ae [Adverse Drug Reaction]
  • procarbazine/dt [Drug Therapy]
  • psychosocial care
  • retinoblastoma/dt [Drug Therapy]
  • sarcoma/co [Complication]
  • sensory neuropathy/si [Side Effect]
  • side effect/si [Side Effect]
  • smoking cessation
  • soft tissue cancer/rt [Radiotherapy]
  • soft tissue sarcoma/dt [Drug Therapy]
  • teniposide/ae [Adverse Drug Reaction]
  • teniposide/dt [Drug Therapy]
  • thyroid cancer/co [Complication]
  • tioguanine/ae [Adverse Drug Reaction]
  • tioguanine/dt [Drug Therapy]
  • vinblastine/ae [Adverse Drug Reaction]
  • vinblastine/dt [Drug Therapy]
  • vincristine/ae [Adverse Drug Reaction]
  • vincristine/dt [Drug Therapy]
  • weakness/si [Side Effect]
  • weight control
  • weight gain

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  • Schmidt D.

  • Anderson L.

  • Bingen K.

  • Hoag J.

  • Kupst M.J.

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