LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models

  • Yamakoshi Y
  • Qiao H
  • Lowell A
 et al. 
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A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.

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  • Yoko Yamakoshi

  • Hui Qiao

  • Andrew N. Lowell

  • Mark Woods

  • Betty Paulose

  • Yuka Nakao

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