Leg patterning driven by proximal-distal interactions and EGFR signaling

  • Galindo M
  • Bishop S
  • Greig S
 et al. 
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wingless and decapentaplegic signaling establishes the proximal-distal axis of Drosophila legs by activating the expression of genes such as Distalless and dachshund in broad proximal-distal domains during early leg development. However, here we show that wingless and decapentaplegic are not required throughout all of proximal-distal development. The tarsus, which has been proposed to be an ancestral structure, is instead defined by the activity of Distalless, dachshund, and a distal gradient of epidermal growth factor receptor (EGFR)-Ras signaling. Our results uncover a mechanism for appendage patterning directed by genes expressed in proximal-distal domains and possibly conserved in other arthropods and vertebrates.

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  • M. I. Galindo

  • S. A. Bishop

  • S. Greig

  • J. P. Couso

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