Leg patterning driven by proximal-distal interactions and EGFR signaling

  • Galindo M
  • Bishop S
  • Greig S
 et al. 
  • 64

    Readers

    Mendeley users who have this article in their library.
  • 120

    Citations

    Citations of this article.

Abstract

wingless and decapentaplegic signaling establishes the proximal-distal axis of Drosophila legs by activating the expression of genes such as Distalless and dachshund in broad proximal-distal domains during early leg development. However, here we show that wingless and decapentaplegic are not required throughout all of proximal-distal development. The tarsus, which has been proposed to be an ancestral structure, is instead defined by the activity of Distalless, dachshund, and a distal gradient of epidermal growth factor receptor (EGFR)-Ras signaling. Our results uncover a mechanism for appendage patterning directed by genes expressed in proximal-distal domains and possibly conserved in other arthropods and vertebrates.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • M. I. Galindo

  • S. A. Bishop

  • S. Greig

  • J. P. Couso

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free