Lentiviral vectors to study stochastic noise in gene expression

  • Franz K
  • Singh A
  • Weinberger L
  • 32


    Mendeley users who have this article in their library.
  • 3


    Citations of this article.


Lentiviral vectors are vehicles for gene delivery that were originally derived from the human immunodeficiency virus type-1 (HIV-1) lentivirus. These vectors are defective for replication, and thus considered relatively safe, but are capable of stably integrating into the genomic DNA of a broad range of dividing and nondividing mammalian cell types. The ability to stably integrate at semi-random genomic positions make lentiviral vectors a unique and ideal tool for studying stochastic variation in gene expression. Here, we describe the experimental and mathematical methods for using lentiviral vectors to study stochastic noise in gene expression. © 2011 Elsevier Inc. All rights reserved.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Kate Franz

  • Abhyudai Singh

  • Leor S. Weinberger

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free