Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins can fold in seconds or less. Mathematical analysis of a simple model shows that a small and physically reasonable energy bias against locally unfavorable configurations, of the order of a few kT, can reduce Levinthal's time to a biologically significant size.
CITATION STYLE
Zwanzig, R., Szabo, A., & Bagchi, B. (1992). Levinthal’s paradox. Proceedings of the National Academy of Sciences of the United States of America, 89(1), 20–22. https://doi.org/10.1073/pnas.89.1.20
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