Levinthal's paradox.

  • Zwanzig R
  • Szabo A
  • Bagchi B
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Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins can fold in seconds or less. Mathematical analysis of a simple model shows that a small and physically reasonable energy bias against locally unfavorable configurations, of the order of a few kT, can reduce Levinthal's time to a biologically significant size.

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  • R. Zwanzig

  • A. Szabo

  • B. Bagchi

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