Lifestyle factors and the risk of adult leukemia in Canada.

  • Kasim K
  • Levallois P
  • Abdous B
 et al. 
  • 14

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

OBJECTIVES: To evaluate the impact of active smoking, obesity, and dietary intakes on the risk of adult leukemia. METHODS: We analysed data obtained from a population-based case-control study conducted in eight Canadian provinces. Risk estimates were generated by applying multivariate logistic regression methods to 1068 incident histologically confirmed leukemia cases and 5039 controls aged 20-74. RESULTS: We found a statistically significant increased risk for acute myeloid leukemia (AML) associated with active smoking, with a clear dose-response relationship and an adjusted odds ratio (OR) of 1.5 (95% confidence interval [CI]=1.1-2.0) for heavy smokers reporting more than 20 pack-years of cigarette smoking. We also observed positive associations with the highest body mass index (BMI) for AML, chronic myeloid leukemia, and chronic lymphoid leukemia with a significant dose-response relationship. No association with leukemia was observed for the intake of fruits and vegetables, and the effect of active smoking on adult leukemia risk was not modified by fruits and/or vegetables consumption or obesity. However, the positive risk for AML associated with active smoking disappeared among subjects with high BMI (> or =30 kg/m2). CONCLUSIONS: Our study contributes to the accumulating evidence linking AML and active smoking, and provides some evidence that obesity increases the risk of most of the adult leukemia subtypes.

Author-supplied keywords

  • Age Distribution
  • Benzene
  • Body Mass Index
  • Canada
  • Case-Control Studies
  • Diet
  • Female
  • Fruit
  • Humans
  • Leukemia
  • Life Style
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Obesity
  • Occupational Exposure
  • Radiation, Ionizing
  • Smoking
  • Solvents
  • Tobacco Smoke Pollution
  • Vegetables
  • adverse effects
  • epidemiology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Authors

  • Khaled Kasim

  • Patrick Levallois

  • Belkacem Abdous

  • Pierre Auger

  • Kenneth C Johnson

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free