Limb blood flow and vascular conductance are reduced with age in healthy humans: Relation to elevations in sympathetic nerve activity and declines in oxygen demand

  • Dinenno F
  • Jones P
  • Seals D
 et al. 
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Abstract

BACKGROUND: We tested the hypothesis that basal (resting) limb blood flow and vascular conductance are reduced with age in adult humans and that these changes are related to elevations in sympathetic vasoconstrictor nerve activity and reductions in limb oxygen demand. METHODS AND RESULTS: Sixteen young (28+/-1 years; mean+/-SEM) and 15 older (63+/-1 years) healthy normotensive adult men were studied. Diastolic blood pressure and body fat were higher (P

Author-supplied keywords

  • Aging
  • Perfusion
  • Regional blood flow
  • Ultrasonics
  • Vasoconstriction

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Authors

  • Frank A. Dinenno

  • Pamela P. Jones

  • Douglas R. Seals

  • Hirofumi Tanaka

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