A lineage of myeloid cells independent of Myb and hematopoietic stem cells

  • Schulz C
  • Gomez Perdiguero E
  • Chorro L
 et al. 
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia--cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

Author-supplied keywords

  • Animals Cell Lineage Cell Proliferation Chick Embr

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Authors

  • C Schulz

  • E Gomez Perdiguero

  • L Chorro

  • H Szabo-Rogers

  • N Cagnard

  • K Kierdorf

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free