Linkage analysis in dominant optic atrophy.

  • Kivlin J
  • Lovrien E
  • Bishop D
 et al. 
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Abstract

A kindred of German descent was studied for dominant optic atrophy, type Kjer (McKusick catalog no. 16540). One hundred twenty-three family members were examined clinically, and 36 affected, 81 normal, and six uncertain members were ascertained. Twenty-seven markers were analyzed for 121 members. The maximum lod score obtained was 2.0 at theta = .18 for linkage between the Kidd locus and dominant optic atrophy. Twenty-eight offspring were informative with 2-generation data. There was insufficient information for the acid phosphatase locus to aid gene localization. These data suggest that the locus for dominant optic atrophy is on chromosome 2.

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  • SCOPUS: 2-s2.0-0021051004
  • ISSN: 0002-9297
  • PUI: 14201171
  • SGR: 0021051004

Authors

  • J.D. Kivlin

  • E.W. Lovrien

  • D.T. Bishop

  • I.H. Maumenee

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